Beilstein J. Org. Chem.2014,10, 3038–3055, doi:10.3762/bjoc.10.322
columns.
Keywords: ethopropazine; lipase-catalyzed kinetic resolution; Moshermethodology; promethazine; stereodivergent synthesis; Introduction
Since enantiomorphs of biologically active compounds exhibit significant differences in their pharmacokinetic and pharmacodynamic behavior, optical purity of
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Graphical Abstract
Scheme 1:
Chemoenzymatic synthesis of enantioenriched enantiomers of promethazine 9 and ethopropazine 10. Rea...